📋 Indications & Clinical Dosage
*Septicaemia, endocarditis, urinary tract infection, respiratory tract, skin and soft tissue infections:*
BY IM OR IV INJ: Adults: 500 mg-1 gm 6-8 hourly. Children1 month: 25-50 mg/kg daily in three or four divided doses.
*Prophylaxis against bacterial endocarditis:*
Adults: 1gm30 min before procedure. Children: 25 mg/kg 30 min before procedure; max dose 1 gm.
*Bone and joint infections:*
BY IM OR IV INJ: Adults: 500-1000 mg every 6-8 hourly. Children: 25-50 mg/kg/day divided every 6-8 hourly doses; max: 100 mg/kg/day.
*Septicaemia:*
BY IV INJ: Adults: 1-1.5 gm every 6 hourly. Children: 100 mg/kg/day divided every 6-8 hourly doses.
💊 Mode of Administration
IM: Inject deep IM into large muscle mass. IV: Inject direct IV over 5 min. Infuse intermittent infusion over 30-60 min.
⚠️ Precautions & Warnings
Hypersensitivity to beta-lactam antibiotics, impaired hepatic and renal function.
🔄 Drug Interactions
: Loop diuretics, probenecid, aminoglycosides.
⚠️ Adverse Reactions / Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, hallucinations, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis
🧪 Compatibility & Storage Stability
Compatibility: Stable in D5W, D5LR, 051/4 NS, D5/ NS, D5NS, 010W, LR, NS. Standard diluent: 1 g/50 ml D5W; 2 g/50 ml D5W.
Stability & Storage: Store intact vial at room temperature and protect from temperatures exceeding 40C. Reconstituted solutions are stable 24 hours at room temperature and 10 days under refrigeration.