📋 Indications & Clinical Dosage
*Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria:*
ORAL: Adult: 250 mg every 6 hours, alternatively 500 mg every8-12 hours; increased to 1-1.5 g every 6-8 hours for severe infections.
Children 1 month-4 years: 12.5 mg/kg twice daily, alternatively125 mg twice daily; 5-11 years: 12.5 mg/kg twice daily, alternatively 250 mg 3 times a day; 12-17 years: 500 mg 2-3 times a day, double the dose in severe infections.
*Urinary Tract Infection:*
ORAL: Adults: 250 mg every 6 hr.
*Prophylaxis of recurrent urinary-tract infection:*
ORAL: Adult: 125 mg once daily, dose to be taken at night.
Children: 12.5 mg/kg once daily (max. per dose 125 mg), dose to be taken at night.
*Upper & Lower Respiratory Infection:*
ORAL: Adults: 250 mg every 6 hr; max: 4 gm/day.
Children: 25-50 mg/kg/day in divided doses.
*Streptococcal Pharyngitis:*
ORAL: Adults: 500 mg every 12 hr; max: 4gm/day.
Children above 1 yr: 25-50 mg/kg/day given every 12 hr.
*Otitis Media:*
ORAL: Children: 75-100 mg/kg/day given every 6 hr.
*Skin Infection:*
ORAL: Adults: 500 mg every 12 hr; max: 4 gm/day.
Children: 25-50 mg/kg/day given every 12 hr.
*Uncomplicated Cystitis:*
ORAL: Adults: 500 mg every 12 hr for 7-14 days; max: 4 gm/day.
Children: 25-50 mg/kg/day in divided doses.
*Bone Infection:*
ORAL: Adults: 250 mg every 6 hr; max: 4 gm/day.
Children: 25-50 mg/kg/day in divided doses.
⚠️ Adverse Reactions / Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, hallucinations, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis