📋 Indications & Clinical Dosage
*Susceptible infections of upper and lower respiratory tract, genito-urinary tract, skin & soft-tissue, bone and joints, and Gonococcal infections:*
ORAL Susp: Children below 2 yrs: 250 mg eight hourly; 2-12 yrs: 250-500 mg eight hourly.
ORAL TAB: Adults: 1 tabof 500 mg eight hourly. In severe case: 1 g eight hourly
BY IM OR IV INJ: Adults: 375mg- 3gm Sulbactam per day, according to severity of infection, in divided doses administered every 8 hr. Children: 50 mg/kg/day sulbactam, in divided doses administered every 8 hr. See literature.
⛔ Contraindications
: Hypersensitivity to penicillins, cephalosporins or other beta-lactams.
⚠️ Precautions & Warnings
Hepatic and renal impairment, risk of crystalluria with high doses, all should be well hydrated. Monitor renal, hepatic and haematological function in neonates.
🔄 Drug Interactions
Anticoagulants, allopurinol, probenecid, disulfiram, probenecid, methotrexate, oral contraceptives
⚠️ Adverse Reactions / Side Effects
GI disturbances, nausea, vomiting, constipation, dyspepsia, headache, hypotension, injection-site reactions, hypersensitivity reaction. Rarely hepatitis, cholestatic jaundice, haematological and CNS ef-fects, pseudomembranous colitis, increased INR.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
No evidence of harm
Lactation / Breastfeeding:
Caution advised