TACIP

*Pneumonia, Septicaemia, Complicated infections of urinary-tract, respiratory tract, abdominal, skin & soft-tissues:* BY SLOWIV INJ OR IV INF: Adult: 4.5 g every 8 hours; increased if necessary to4.5 g every 6 hours, increased frequency may be used for severe infections. *Infections in neutropenic patients:* BY SLOW IV INJ OR IV INF: Adult: 4.5 g every 6 hourswith aminoglycosides. Children: 90 mg/kg 6 hourly with aminoglycosides; max 4.5 gm six hourly. *Appendicitis:* BY SLOWIV INJ OR IV INF: Adult: 4.5 g every 8 hours; increased if necessary to4.5 g every 6 hours. Children 2-12 yr: 112.5 mg/kg eight hourly; max 4.5 gm eight hourly.

IV: Administer by IV infusion over 30 min. Use single-dose vials immediately after reconstitution (discard unused portions after 24 hours at room temperature and 48 hours if refrigerated). Reconstitute with 5 ml of diluent per 1 gm of piperacillin and then further dilute. Compatible diluent include NS, SWFI, dextran 6%, D5W, D5W with potassium chloride 40 mEq, bacteriostatic saline and water.

Hypersensitivity to penicillins, cephalosporins or other beta-lactams.

Renal or hepatic failure, patients with low K+ reserves.High doses may lead to hypernatraemia

Probenecid, drugs affecting blood Coagulation and/or thrombocyte function, non-depolarising muscle re-laxants, methotrexate.

GI disturbances, nausea, vomiting, constipation, dyspepsia, headache, hypotension, injection-site reactions, insomnia, jaundice, stomatitis. Rare: eosinophilia, hepatitis, hypoglycaemia, hypokalaemia, pancytopenia, Steven-Johnson syndrome, toxic epidermal necrolysis, allergic re-actions