📋 Indications & Clinical Dosage
*Homozygous familial hypercholesterolaemia, primary hypercholesterolaemia, and mixed hyperlipidaemia, or for patients not adequately controlled by statin alone:*
Adults: 1 tab of 10/20 mg as single dose in evening. Adjust at minimum 4 wk intervals according to response, max 10 mg ezetimibe and 80 mg simvastatin daily.
Children: Not recommended.
⛔ Contraindications
Active liver disease, moderate or severe liver impairment.
⚠️ Precautions & Warnings
Severe renal impairment. Perform liver function tests before and during treatment, history of liver disease. Advise patients to report unexplained muscle weakness or pain; monitor creatine kinase levels, renal impairment, hypothyroidism, history of muscle toxicity, family or personal history of muscle disorders, alcohol abuse, elderly
🔄 Drug Interactions
Digoxin, coumarin anticoagulants, cyclosporin, danazol, amiodarone, verapamil, diltiazem, gemfibrozil and other fibrates, nicotinic acid, erythromycin, clarithromycin, telithromycin, itraconazole, ketoconazole, other CYP3A4 inhibitors, immunosuppressants, nefazodone, protease inhibitors, grapefruit juice, colestipol, cholestyramine.
⚠️ Adverse Reactions / Side Effects
Headache, flatulence, myalgia, abdominal pain, diarrhoea, fatigue.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.