📋 Indications & Clinical Dosage
*Adjunct to diet in primary hypercholesterolaemia for patients not appropriately controlled with a statin alone, Adjunct to diet in homozygous familial hypercholesterolaemia:*
Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.
⛔ Contraindications
Active liver disease or unexplained persistent elevations of serum transaminases >3x the upper limit of normal, women of childbearing potential who are not using adequate contraceptive measures.
⚠️ Precautions & Warnings
Heart failure, impaired hepatic function; perform liver function tests before initiating treatment & periodically thereafter, history of liver disease, discontinue drug if markedly elevated CPK levels occur or myopathy is diagnosed or suspected, risk factor predisposing to development or renal failure
🔄 Drug Interactions
Fibrates, cyclosporin, cholestyramine, colestipol, azole antifungals, niacin, drugs metabolised by cytochrome P450 3A4, digoxin, erythromycin, oral contraceptives, antacids, warfarin.
⚠️ Adverse Reactions / Side Effects
Flushing, fatigue, oedema, dizziness, headache, abdominal pain, nausea, palpitations, somnolence, Insomnia, headache, GI disturbances, myalgia, asthenia, elevated ALT and CPK levels.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.