NIXETIL

*Hypertension:* Adult: Initially 8 mg once daily, increased if necessary up to 32 mg once daily, increased at intervals of 4 weeks; usual dose 8 mg once daily. Children 6-18 yrs: initially 4 mg once daily (reduced dose in intravascular volume depletion), adjusted according to response, max 8 mg once daily. *Hypertension with intravascular volume depletion:* Adult: Initially 4 mg once daily, increased if necessary up to 32 mg daily, increased at intervals of4 weeks; usual dose 8 mg once daily. *Heart failure with impaired left ventricular systolic function when ACE inhibitors are not tolerated or in conjunction with an ACE inhibitor:* Adult: Initially 4 mg once daily, increased at intervals of at least 2 weeks to required dose of 32 mg once daily or to max. tolerated dose.

Severe hepatic impairment, cholestasis.

Correct volume/salt depletion before starting ther-apy, anaesthesia, renal impairment; monitor serum potassium and creatinine, severe renal impairment, haemodialysis; carefully titrate dose and monitor BP thoroughly, renal artery stenosis, aortic or mitral stenosis, kidney transplant, obstructive hypertrophic cardiomyopathy, severe congestive heart failure, mild to moderate hepatic impairment, primary hyperaldosteronism.

K+-sparing diuretics, K+-supplement, lithium.

Headache, vertigo. Rare: Arthralgia, back pain, blood disorders, cough, hepatitis, hyponatraemia, myalgia, nausea, pruritus, rash, urticaria