📋 Indications & Clinical Dosage
*Hypertension in patients stabilised on the individual components in the same proportions:*
Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.
⛔ Contraindications
Hepatic or severe renal impairment, cardiogenic shock, acute MI, unstable angina.
⚠️ Precautions & Warnings
Salt or volume depletion, severe congestive heart failure, renal disease, renal artery stenosis, aortic or mitral valve stenosis, obstructive hypertrophic cardiomyopathy, primary aldosteronism. Mild to moderate renal impairment; monitor serum potassium in patients at risk of hyperkalaemia.
🔄 Drug Interactions
Lithium, K-supplements, K+-sparing diuretics, salt substitutes, NSAIDs, CYP3A4 inducers and inhibitors, sildenafil.
⚠️ Adverse Reactions / Side Effects
Arthritis, chest pain, cough, fatigue, GI disturbances, haematuria, hypertriglyceridaemia, hyperuricaemia, influenza-like symptoms, musculoskeletal pain, peripheral oedema, pharyngitis, rhinitis, urinary-tract infection. Rare: Angina, vertigo, headache, myalgia, pruritus, thrombocytopenia, urticaria
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.