📋 Indications & Clinical Dosage
*Prophylaxis of angina, Hypertension:*
Adult: Initially 5 mg once daily; max. 10 mg per day. No dose adjustment required when administered concurrently with thiazide diuretics, beta-blockers, ACE inhibitor.
Children 6-12 yrs: initially 100-200 mcg/kg once daily; if necessary increase at intervals of 1-2 wk. up to 400 mcg/kg once daily; max 10 mg once daily; 12-18 yrs: initially 5 mg once daily; if necessary increase at intervals of 1-2 wk. to max 10 mg once daily.
⛔ Contraindications
Cardiogenic shock, aortic stenosis, unstable angina, hypersensitivity to dihydropyridines.
🔄 Drug Interactions
Azole antifungals, erythromycin, cyclosporin, sildenafil, rifampicin, CYP3A4 inhibitors.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, headache, oedema, palpitations, fatigue, nausea, flushing and dizziness, rash, gingival hyperplasia. Rare: Alope- cia, pruritus, angioedema, dyspnoea, abdominal pain, back pain, dyspepsia, muscle cramps, asthenia, somnolence, altered bowel habit, myalgia, arthralgia, peripheral neuropathy, pancreatitis, mood changes, dry mouth, increased micturition, hyperglycaemia, impotence, sweating, syncope, thrombocytopenia, vasculitis, visual disturbances.