📋 Indications & Clinical Dosage
*Hypertension:*
Adult: Initially 2.5/25 mg daily, increased if necessary up to 5/50 mg daily
*Congestive heart failure:*
Adult: Initially 2.5/25 mg daily; increased if necessary up to 10/100 mg daily, reduce dose for maintenance if possible.
*Oedema and ascites in cirrhosis of the liver:*
Adult: Initially 5/50 mg daily; increased if necessary up to 10/100 mg daily, reduce dose for maintenance if possible.
Children: Not recommended.
⛔ Contraindications
Addisons disease,anuria, hypercalcaemia, hyponatraemia, refractory hypokalaemia, symptomatic hyperuricaemia
⚠️ Precautions & Warnings
Diabetes, acidosis, gout, renal or hepatic im-pairment, hyperaldosteronism, malnourishment, nephrotic syndrome, systemic lupuserythematosus
🔄 Drug Interactions
K+ supplement; K+ sparing diuretics, digitalis, lithium, antihypertensives, ACE inhibitors.
⚠️ Adverse Reactions / Side Effects
Agitation,alopecia, angina,anorexia,arrhythmias,arthralgia,confusion,cough,dizziness,dry mouth, dyspnea,encephalopathy,fever, flushing, GI disturbance and bleeding, headache, hyperkalaemia, insomnia, jaundice, malaise, musclecramp, nasalcongestion, nausea, palpitation, paraesthesia, postural hypotension, pruritus, raised intra-ocular pressure, rash, respiratory distress, restlessness, sexual dysfunction, sweating, thirst, tinnitus, tremor, urinary disturbances, visual disturbance