📋 Indications & Clinical Dosage
*Acute hypotension:*
BY IV INF: Adults: Initially 0.16-0.33 ml/min, adjust according to response, to be administered via central venous catheter, of a solution containing noradrenaline acid tartrate 80 mcg/ ml (equivalent to noradrenaline base 40 mcg/ ml) Cardiac arrest:
BY IV INJ: Adults: By rapid intravenous or intracardiac injection, 0,5-0.75 ml of a solution containing noradrenaline acid tartrate 200 mcg/ ml (equivalent to noradrenaline base 100 mcg/ ml).
💊 Mode of Administration
By IV infusion into a large vein. A 4 mcg/ml dilution of norepinephrine base for infusion is usually pre-pared by adding 4 mg of base (4 ml) to 1000 ml of D5W with or without NS. Dilute with D5W or D5NS, not recommended to dilute in NS.
⛔ Contraindications
Hypertension (monitor blood pressure and rate of flow frequently).
⚠️ Precautions & Warnings
Coronary, mesenteric, or peripheral vascular thrombosis following myocardial infarction. Prinzmetals variant angina, hyperthyroidism, diabetes mellitus, hypoxia or
hypercapnia, uncorrected hypovolaemia, elderly Extravasation at injection site may cause necrosis.
🔄 Drug Interactions
Beta-blockers, cyclopropane and halothane an-aesthetics, COMT inhibitors, MAOls or TCAs.
⚠️ Adverse Reactions / Side Effects
Angle-closure glaucoma, anorexia, anxiety, arrhythmias, bradycardia, confusion, dyspnea, headache, hypertension, hypoxia, insomnia, nausea, palpitation, peripheral ischaemia, psychosis, tachycardia, tremor, urinary retention, vomiting, weakness
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Caution advised
🧪 Compatibility & Storage Stability
Compatibility: Stable in D5NS, D5W, LR. Avoid contact with iron salts, alkalis, or oxidizing agents. Administer whole blood or plasma separately (i.e. by use of a Y-tube and individual containers if given simultaneously).
Stability & Storage: Stable for 24 hours at room temp. Store at 25C (77F), excursions are permitted to 15C-30C (59F-86F). Protect from light.