📋 Indications & Clinical Dosage
*As adjunctive therapy in the treatment of stable angina inpatients inadequately controlled or intolerant of first-line anti-anginal therapies:*
Adult: Initially 375 mg twice daily for 2-4 weeks, then increased to 500 mg twice daily, then adjusted according to response to 750 mg twice daily; reduced if not tolerated to 375-500 mg twice daily
Children: Not recommended.
⚠️ Precautions & Warnings
Body-weight less than 60 kg, elderly, moderate to severe congestive heart failure,
QT interval prolongation, mild to moderate hepatic &renal impairment.
🔄 Drug Interactions
CYP3A4 inhibitors & inducers, CYP2D6 inhibitors, calcium channel blockers, anti-arrhythmics, anticon-vulsants, macrolides, digoxin, drugs that prolong QT intervals.
⚠️ Adverse Reactions / Side Effects
Asthenia, constipation, dizziness, headache, nausea, vomiting, abdominal pain, anorexia, anxiety, chromaturia, confusion, cough, dehydration, drowsiness, dry mouth, dyspepsia, dysponea, dysuria, epistaxis, flatulence, haematuria, hallucination, hot flush, hypoaesthesia, hypotension, insomnia, joint swelling, lethargy, muscle cramp, pain in extremities, peripheral oedema, prolonged QT interval, pruritus, sweating, syncope, tinnitus, tremor, visual disturbance