📋 Indications & Clinical Dosage
*Local fibrinolysis to prevent bleeding:*
ORAL: Adults: 15-25 mg/kg body weight two-three times daily.
BY SLOW IV INJ:0.5-1 gm slow IV injection 3 times daily.
*Menorrhagia:*
Adult: 1-1.5 gm 3-4 times daily, initiated when heavy bleeding started, for 3-4 days.
*Hereditary angioedema:*
Adult: 1-1.5 gm 2-3 times daily.
*General fibrinolysis:*
Adult: 1 gm (or 15 mg/kg)every 6-8 hr.
*Inhibition of fibrinolysis, hereditary angioedema:*
ORAL: Children 1 mth-18 yr: 15-25mg/kg (max 1.5 gm) 2-3 times daily.
BY IV INJ: Children 1-18 yr: 10 mg/kg (max 1 g,) 2-3times daily IV injection over at least 10minutes.
BY CONTINUOUS IV INF: Adult: 45 mg/kg over 24 hr. Not recommended for children below 1 year of age.
*Prevention of excessive bleeding after dental procedures (inhaemophiliac):*
BY IV INJ: Pre-operatively, Children 6-18 yrs:10 mg/kg (max 1.5 gm).
ORAL: Pre-operatively, Children6-18 yrs: 15-25 mg/kg (max 1.5 gm). Postoperatively, Children 6-18 yr:15-25 mg/kg (max 1.5 gm) 2-3 times daily forup to 8 days.
💊 Mode of Administration
IV injection or administer as IV continuous infusion. 25-50 .09 over 24hours. Can be mixed with solutions forinfusion such as NS or DOW.
⛔ Contraindications
thromboembolism, renal disease, color blindness, haematuria.
⚠️ Precautions & Warnings
Perform regular eye examinations and liver function tests in long-term treatment of hereditary angioedema.
⚠️ Adverse Reactions / Side Effects
Renal failure, myopathy, intracranial thrombosis, gastrointestinal disorders, nausea, vomiting, diarrhoea, purpura, colour vision disturbances (discontinue) giddiness on rapid IV injection.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised, avoid
Lactation / Breastfeeding:
Caution advised
🧪 Compatibility & Storage Stability
Stability & Storage: Store at 15.C-30.0 (59F-86F).