📋 Indications & Clinical Dosage
*Severe renal impairment requiring vitamin D therapy:*
ORAL OR BY IV INJ: Adult: Initially 1 microgram daily, oral or IV injection over 30 sec, adjusted dose to avoid hypercalcaemia; maintenance0.25-1 microgram daily.
Elderly: Initially 500 nanograms daily, adjusted dose to avoid hypercalcaemia; maintenance 0.25-1 microgramdaily
*Hypophosphataemic rickets, Persistent hypocalcaemiadue to hypoparathyroidism or pseudo hypoparathyroidism:*
ORAL OR BY IV INJ: Children 1 month-11 yrs: 25-50 nanograms/kg oral or IV injection over 30 sec, once daily; max.1 microgram per day.
Children 12 & above: 1 microgram once daily, oral or IV injection over 30 sec.
*Prevention of vitamin D deficiency in renal or cholestaticliver disease:*
ORAL OR BY IV INJ: Children 1 month-11 yrs:(body-weight up to20 kg):15-30 nanograms/kg once daily; max. per dose 500nanograms; (body-weight 20 kg andabove): 250-500 nanograms once daily, oral or IV injection over 30 sec
Children 12yrs& above: 250-500 nanograms once daily.
One drop of alfacalcidol 2 microgram/ml oral drops contains approximately 100 nanograms alfacalcidol, oral or IV injection over 30 sec
⛔ Contraindications
Hypercalcaemia, metastatic calcification.
⚠️ Precautions & Warnings
Caution advised.
🔄 Drug Interactions
Barbiturates, anticonvulsants, danazol, digitalis, thiazides, antacids, colestipol, sucralfate mineral oils, cholestyramine
⚠️ Adverse Reactions / Side Effects
Rare: nephrocalcinosis, pruritus, rash, urticaria. Symptoms of overdose include anorexia, lassitude, weight loss, GI disorders, polyuria, sweating, headache, thirst, vertigo, and raised concentration of calcium and phosphate in plasma and urine.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Risk cannot be ruled out.