📋 Indications & Clinical Dosage
*Type 2 diabetes not controlled by metformin alone, particularly in obese:*
Adults: One tab of 30 mg/2 mg once daily or 15 mg/4 mg once daily, (the dosage of glimepiride is to be reduced in case of hypoglycaemia). The dosage can be increased to 30 mg/4 mg once daily.
Children: Not recommended.
⛔ Contraindications
History of heart failure, previous or active bladder cancer, uninvestigated macroscopic haematuria, dialysis, diabetic ketoacidosis, pregnancy and lactation.
⚠️ Precautions & Warnings
Porphyrias, Monitor for fluid retention or other signs of cardiac failure (discontinue if deteriorates). Monitor for signs of hepatic dysfunction and check liver enzymes prior to therapy and every 2 months thereafter, elderly, risk of bone fracture and bladder cancer particularly in women and elderly.
🔄 Drug Interactions
Insulin (contraindicated), NSAIDs, gemfibrozil, rifampicin.
⚠️ Adverse Reactions / Side Effects
GI disturbances, anaemia, arthralgia, dizziness, haematuria, headache, hypoaesthesia, impotence, oedema, vertigo, visual disturbances, weight gain, altered blood lipids, bladder cancer, fatigue, hypoglycaemia, insomnia, proteinuria, sweating. Rare: Liver dysfunction.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated or not recommended
Lactation / Breastfeeding:
Contraindicated or not recommended.