T-NOR

*Nausea and vomiting induced by chemotherapy:* BY SLOW IV INJ OR INF: Adults: 5 mg by slow IV inj or INF shortly before chemotherapy followed by 1 cap each morning 1 hr before food for 5 days. Children above 2 yr: 0.2 mg/kg by slow IV inj or INF shortly before chemotherapy up to a max daily dose of 5 mg. In children under 25 kg, repeat IV administration on day 2 up to day 5 depending on chemotherapy regimen, in children over 25 kg, 5 mg orally on day 2 up to day 6. *Prevention of post-operative nausea and vomiting:* BY SLOW IV INJ OR INF: Adults: 2 mg dose by slow IV or INF shortly before induction of an-aesthesia. *Treatment of post-operative nausea and vomiting:* BY SLOW IV INJ OR INF: Adults: One 2 mg dose by IV or INF within 2 hr of the end of an-aesthesia.

Intermittent or via drip tubing in dextrose 5% or NaCI 0.9% or Ringers solution. Suggested concentrationfor infusion is 50 meg/ ml.

Liver impairment, hypertension, cardiac rhythmor conduction disturbances.

Rifampicin and drugs affecting liver enzymes or prolong QT interval.

Fatigue, dizziness, headache, constipation, GI disturbance, rarely collapse, syncope, bradycardia, cardiovascular arrest.