ENDTRON

*Moderately emetogenic chemotherapy or radiotherapy:* ORAL: Adult: 8 mg, 1-2 hours before treatment, then 8 mg every 12 hrs for up to 5 days. BY RECTUM: Adult: 16 mg, 1-2 hours before treatment, then 16 mg daily for up to 5 days. BY IM INJ, OR BY SLOWIV INJ: Adult: 8 mg, immediately before treatment, then (oral) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days. BY IM INJ, OR BY IV INF: Elderly: 8 mg, immediately before treatment, IV INF to be given over at least 15 minutes, then (oral) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days *Severely emetogenic chemotherapy:* ORAL: Adult: 24 mg, dose to be taken 1-2 hours before treatment, then 8 mg every 12 hours for up to 5 days BY RECTUM: Adult: 16 mg, dose to be administered 1-2 hours before treatment, then 16 mg daily for up to 5 days BY IM INJ, OR BY SLOWIV INJ: Adult: 8 mg, dose to be administered immediately before treatment, followed by (by IM inj or by slow IV inj) 8 mg every 4 hours if required for 2 doses, alternatively, followed by (by continuous IV INF) 1 mg/hour for up to 24 hours, then (oral) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days. Children 6 months-18 yrs: By IV INF over at least 15 minutes, 150 mcg/kg immediately before chemotherapy (max single dose 8 mg) repeated every 4 hr for 2 further doses, then give by mouth; max total daily dose 32mg. Oral dosing can start 12 hr after IV administration; for bodyweight 10 kg or less, 2 mg every 12 hr for up to 5 days (max total daily dose 32 mg); body-weight over 10 kg, 4 mg every 12 hr for up to 5 days (max total daily dose 32 mg); bodyweight over 40 kg, 8 mg every 12 hr for up to 5 days (max total daily dose 32 mg). *Prevention and treatment of postoperative nausea and vomiting:* ORAL: Adult: 16 mg, dose to be taken 1 hour before anaesthesia, BY IM INJ OR BY SLOW IV INJ: Adult: 4 mg, dose to be administered at induction of anaesthesia Children 1 months-18 yrs: 100 mcg/kg (max 4 mg) as a single dose by slow IV injection over at least 30 sec, before, during, or after induction of anaesthesia.

IM: Should be given undiluted. IV: Give first dose 30 min prior to beginning chemotherapy; the IV preparation has been successful when administered orally. IVPB: Infuse over 15-30 min; 24-hour continuous infusions have been reported, but are rarely used. RECONSTITUTION: Prior to IV infusion, dilute in 50-100 ml D5W or NS.

Hepatic impairment, adenotonsillar surgery, sub acute intestinal obstruction, susceptibility to QT-interval prolongation(including electrolyte disturbances).

Tramadol, Phenytoin, rifampicin, carbamazepine,

Constipation, headache, flushing, arrhythmias, bradycardia, chest pain, hiccups, hypotension, movement disorders, seizure, transient rise in liver enzymes, ST segment depression, extra-pyramidal reactions, visual disturbance.