📋 Indications & Clinical Dosage
*Reversible airways obstruction, Severe acute asthma, Chronic asthma:*
Adults & Children above 12 yrs: 175 mg-350 mg twice daily.
Children 2-6 yr: 60-120 mg twice daily; 6-12 yr: 125-250 mg twice daily.
⛔ Contraindications
Acute porphyria, epilepsy, concomitant use of ephedrine in children.
⚠️ Precautions & Warnings
CNS disorder, cardiac arrhythmia, other cardiovascular disease, risk of hypokalaemia, peptic ulcer, hyperthyroidism, hypertension, history of seizures, hepatic dysfunction, acute febrile illness, chronic alcoholism, elderly.
🔄 Drug Interactions
Plasma levels increased by allopurinol, cimetidine, ciprofloxacin, clarithromycin, diltiazem, disulfiram, erythromycin, fluconazole, ketoconazole, fluvoxamine, influenza vaccine, interferon, methotrexate, mexilefine, nizatidine, quinolones, pentoxyfylline, propafenone, propranolol, verapamil. Plasma levels decreased by carbamazepine, primidone, phenytoin, rifampicin, ritonavir, sulfinpyrazone, barbiturates, smoking, St. Johns Wort. Other interactions: beta-agonists, adenosine, benzodiazepines, diuretics, ketamine, halothane, lithium, corticosteroids.
⚠️ Adverse Reactions / Side Effects
CNS stimulation, arrhythmias, headache, convulsions, diarrhoea, gastric irritation, insomnia, nausea, palpitation, tachycardia, vomiting, GI upset, hypotension.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised