TERBUTASCOT

*Asthma, conditions associated with reversible airways obstruction:* ORAL: Adult: Initially 2.5 mg tab 3 times a day for 1-2 weeks, thenincreased to up to 5 mg 3 times a day. Children 7-15 yr: 2.5 mg tab 2 or 3 times daily Children 3-7 yr: 2.5-5 ml syrup 8 hourly; 7-15 yr: 5-10 ml syrup 8 hourly. BY SC INJ, OR BY SLOW IV INJ: Adult: 250-500 mcg up to 4 times a day, use in severe cases where oral therapy is inappropriate or ineffective. BY CONT.IV INF: Adult: 90-300 mcg/hour for 8-10 hours, to be administered as a solution containing 3-5 mcg/ml, high doses require close monitoring, use in severe cases where oral therapy is inappropriate or ineffective. *Acute asthma:* ORAL: Adults: 2.5 mg-5 mg tab 2 or 3 times daily or 10-15 ml syrup 8 hourly. Children 7-15 yr: 2.5 mg tab 2 or 3 times daily. Children 3-7 yr: 2.5-5 ml syrup 8 hourly; 7-15 yr: 5-10 ml syrup 8 hourly. BY SC INJ, OR BY SLOW IV INJ: Children 2-14 yrs: 10 mcg/kg up to 4 times a day(max. per dose 300 mcg); 15-17 years: 250-500 mcg up to 4 times aday, use in severe cases where oral therapy is inappropriate or ineffective. BY CONT.IV INF: Children: Loading dose 2-4 mcg/kg, then1-10 mcg/kg/hour, dose to be adjusted according to response and heart rate, close monitoring is required for doses above 10 mcg/kg/hour, use in severe cases where oral therapy is inappropriate or uneffective. *Exacerbation of reversible airways obstruction (including nocturnal asthma), Prevention of exercise-induced bronchospasm:* ORAL: Children 1 month-6 yrs: 75 mcg/kg 3 times a day (max. per dose 2.5 mg); 7-14 years: 2.5 mg 2-3 times a day; 15-17 years: Initially 2.5 mg 3 times a day, then increased if necessary to 5 mg 3 times a day. *Uncomplicated premature labour:* BY IV INF: Adult: Initially 5 mcg/minute for 20 minutes, then increased in steps of 2.5 mcg/minute every 20 minutes until contractions have ceased (more than 10 mcg/minute should seldom be given; should not be exceeded 20 mcg/minute), continue for 1 hour, then reduced in steps of 2.5 mcg/minute every 20 minutes to lowest dose that maintains suppression (max. total duration 48 hours).

Administered by SC only, usually into the lateral deltoid area.

When used for uncomplicated premature labour: Abruptio-placenta, antepartum haemorrhage, cord compression, eclampsia, history of cardiac disease, intra-uterine infection or fetal death, placenta praevia, pulmonary hypertension, severe pre-eclampsia, risk factors for myocardial ischaemia, threatened miscarriage

Mild to moderate pre-eclampsia, suspected cardiovascular disease, myocardial insufficiency, angina, cardiac arrhythmias, hypertension, hyperthyroidism, young children

Sympathomimetics, beta-blockers, hypokalaemic agents.

Muscle tension, nausea, pulmonary oedema (with injection use) vomiting, tremor, peripheral vasodilation, tension, headache, sleep and behavioural disturbances in children.