📋 Indications & Clinical Dosage
*Adjunct to bronchodilators maintenance treatment of severe chronic obstructive pulmonary disease associated with chronic bronchitis and a history of frequent exacerbations:*
Adult: 500 mcg once daily.
⛔ Contraindications
Moderate to severe cardiac failure, moderate to severe hepatic impairment, history of depression associated with suicidal ideation or behavior, severe acute infections, cancer, concomitant treatment with immunosuppressive drugs, severe immunological disease
⚠️ Precautions & Warnings
History of psychiatric illness; discontinue if new or worsening psychiatric symptoms occur, latent infection (such as tuberculosis, viral hepatitis, herpes infection), mild hepatic impairment. Monitor body-weight
🔄 Drug Interactions
Aminophylline, antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone), combined hormonal contraceptives, enzalutamide, H2 receptor antagonists (cimetidine), quinolones (ciprofloxacin), rifampicin, SSRIs (fluvoxamine), Theophylline
⚠️ Adverse Reactions / Side Effects
Abdominal pain, decreased appetite, diarrhoea, headache, insomnia, nausea, weight loss, anxiety, dizziness, dyspepsia, gastritis, GORD, constipation, malaise, muscle spasm, myalgia, palpitation, rash, tremor, vertigo .Rare: Depression, gynaecomastia, haematochezia, nervousness, raised creatine kinase, respiratory tract infections, suicidal behavior, suicidal ideation, taste disturbances, urticaria
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised