📋 Indications & Clinical Dosage
*Relief of nausea and vomiting:*
BY IV INJ: Adults: With chemotherapy 1-40 mg IV (usually 1mg/ kg). See literature.
ORAL: Adult & Children 12yrs (body-weight 35 kg and above): 10 mg up to 3 times a day; max. 30 mg per day.
Children (body-weight up to 35 kg): 250 mcg/kg up to 3 times a day; max. 750 mcgr/kg per day.
Children below 12yrs: Not recommended.
*Epigastria, sense of fullness, upper abdominal distention, regurgitation, and Gastro-intestinal pain in palliative care:*
ORAL: Adult: 10 mg 3 times a day, before meals.
⛔ Contraindications
Cardiac disease, when administered concomitantly with drugs that prolong the QT interval or potent CYP3A4 inhibitors, Hepatic impairment, Prolactinoma, GI haemorrhage, mechanical perforation or obstruction.
⚠️ Precautions & Warnings
Children, if there are cardiac concerns, obtain
ECG before and during treatment, patients
over 60 years, increased risk of ventricular arrhythmia, renal impairment.
🔄 Drug Interactions
Erythromycin, Ketoconazole, ritonavir.
⚠️ Adverse Reactions / Side Effects
Drowsiness, dry mouth, malaise
Anxiety, diarrhoea, galactorrhoea, headache, pruritus, rash,
Agitation, amenorrhoea, convulsions, extra pyramidal disorders, gynaecomastia, nervousness, oculogyric crisis, QT-interval prolongation, sudden cardiac death, urinary retention, ventricular arrhythmias, GI upset, raised serum prolactin
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Not recommended.