📋 Indications & Clinical Dosage
*Prophylaxis and treatment of plasmodium falciparum malaria:*
Prophylaxis: Adult: Non-immune patient: 1 tab as a single dose once in a week; Semi-immune patient: 2-3 tab once every four weeks.
Children below 4 yr: quarter adult dose; 4-8 yr: half adult dose; 9-14 yr, three-quarters adult dose.
Treatment: Adult & Children above 14 yr: 2-3 tab as a single dose. Children: Below 4 yr, 1/2 tab; 4-8 yr, 1 tab; 9-14 yr, 2 tab. All as a single dose.
SUSPENSION: Treatment: Adults: 15 ml in single dose. Children: Single dose: below 4 yr: 2.5 ml; 4-6 yr: 5 ml; 7-9 yr: 7.5 ml; 10- 14 yr, 10 ml.
Prophylaxis: Adults: Non-immune patient, 5 ml as a single dose once in a wk; Semi-immune patient, 10-15 ml once every four wk.
Children below 4 yr: 2.5 ml as a single dose; 4-8 yr: 5 ml as a single dose; 9-14 yr: 7.5 ml as a single dose.
⛔ Contraindications
Severe liver or kidney dysfunction, Sulphonamide sensitivity, blood dyscrasias, neonates.
⚠️ Precautions & Warnings
Impaired renal or hepatic function, porphyria, psoriasis, severe gastrointestinal, neurological or blood disorders.Perform regular blood counts during long-term prophylaxis. Avoid excess sunlight exposure
🔄 Drug Interactions
Folate inhibitors.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, headache, nausea, flushing, skin rash (discontinue immediately), pharyngitis or pruritus occurs, GI distress, blood dyscrasias. Rarely erythema multiforme, Stevens-Johnson syndrome, Lyells syndrome.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Contraindicated or not recommended.