📋 Indications & Clinical Dosage
*Anaerobic infections:*
Adult: Initially 2 g, followed by 1 g daily usually for 5-6 days, alternatively 500 mg twice daily usually for 5-6 days.
*Bacterial vaginosis, Acute ulcerative gingivitis:*
Adult: 2 g for 1 single dose.
*Abdominal surgery prophylaxis:*
Adult: 2 g for 1 single dose, to be administered approximately 12 hours before surgery.
*Intestinal amoebiasis:*
Adult: 2 g once daily for 2-3 days
Children 1 month-11 yrs: 50-60 mg/kg once daily (max. per dose 2 g) for 3 days; 12-17 years: 2 g once daily for 2-3 days.
*Amoebic involvement of liver:*
Adult: 1.5-2 g once daily for 3-6 days.
Children 1 month-11 yrs: 50-60 mg/kg once daily (max. per dose 2 g) for 5 days; 12-17 yrs: 1.5-2 g once daily for 3-6 days.
*Urogenital trichomoniasis, Giardiasis:*
Adult: 2 g for 1 single dose.
Children 1 month-11 yrs: 50-75 mg/kg (max. per dose 2 g) for 1 single dose, dose may be repeated once if necessary; 12-17 yrs: 2 g for 1 single dose, dose may be repeated once if necessary.
*Helicobacter pylori eradication:*
Adult: (consult local protocol).
⛔ Contraindications
Blood dyscrasias, neurological disorders.
⚠️ Precautions & Warnings
Avoid in acute porphyrias
🔄 Drug Interactions
Alcohol
⚠️ Adverse Reactions / Side Effects
Anorexia, furred tongue, GI disturbances, nausea, oral mucositis, taste disturbances, vomiting, urticaria, angioedema, CNS disturbances, dark urine, neuropathy and leucopenia on long term therapy.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated