📋 Indications & Clinical Dosage
*Adjunctive treatment of cortical myoclonus:*
Adult: Initially 7.2 g daily in 2-3 divided doses, then increased in steps of 4.8 g every 3-4 days, adjusted according to response, subsequently, attempts should be made to reduce dose of concurrent therapy; max. 24 g per day.
BY IV INJ: Adults: 1 gm IV 3 times per day. In sub-acute indications: Adults: 3 amps twice daily; Acute indications: Adults: 3 amp four times daily.
Children: 30-50 mg/kg/day.
💊 Mode of Administration
The injectable ampoules administered IV over several mins. The infusion is administered continuously at the recommended daily dose over a 24 hr period.
⛔ Contraindications
Huntingtons chorea, severe renal insufficiency, hepatic impairment, cerebral haemorrhage.
⚠️ Precautions & Warnings
Gastric ulcer, history of haemorrhagic stroke, increased risk of bleeding, major surgery, underlying disorders of haemostasis, renal impairment, elderly. Withdraw therapy gradually.
🔄 Drug Interactions
Thyroid hormones.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, anxiety, asthenia, ataxia, confusion, depression, dermatitis, diarrhoea, drowsiness, hyperkinesia, nervousness, weight gain, haemorrhagic disorder, hallucination, headache, insomnia, nausea, pruritus, urticaria, vertigo, vomiting, rash.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated