IMIDOL

*Depressive illness:* Adult: Initially up to 75 mg daily in divided doses, then increased to 150-200 mg daily, up to 150mg may be given as a single dose at bedtime, dose to be increased gradually; up to 300 mg in hospital patients. Elderly: Initially 10 mg daily, increased to 30-50 mg daily, dose to be increased gradually. *Nocturnal enuresis:* Child 6-7 years: 25 mg once daily at bedtime, initial period of treatment (including gradual withdrawal) 3 months; full physical examination before further course; 8-10 years: 25-50 mg once daily at bedtime, initial period of treatment (including gradual withdrawal) 3 months-full physical examination before further course; 11-17 years: 50-75 mg once daily at bedtime, initial period of treatment (including gradual withdrawal) 3 months-full physical examination before further course.

Acute porphyrias, arrhythmia, immediate recovery period after myocardial infarction, during the manic phase of bipolar disorder, heart block

Cardiovascular disease, diabetes, epilepsy, chronic constipation, history of bipolar disorder, history of mania and psychosis, hyperthyroidism, prostatic hypertrophy, increased intra-ocular pressure, patients with a significant risk of suicide, phaeochromocytoma, susceptibility to angle-closure glaucoma, urinary retention, hepatic impairment (contraindicated if severe),concurrent ECT. Withdraw gradually

15 days of MAOls. Other antidepressants, St. Johns Wort, tramadol, drugs that prolong the QT interval (e.g. anti-arrhythmics), moxifloxacin, anticonvulsants, diltiazem, verapamil, clonidine, other antihypertensives, antipsychotics, sotalol, dopaminer_x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004__x0004_s_x0004_r_x0004_a_x0004_c_x0004_u_x0004_t_x0004_c_x0002_v?_x0001_????

Agitation, alopecia, anorexia, anxiety, arrhythmia, blurred vision, fatigue, flushing, headache, palpitation, restlessness, chills, confusion, convulsions, delusions, dizziness, drowsiness, dry mouth, dysarthria, ECG changes, galactorrhoea, gynaecomastia, haematologial reactions, hallucinations, headache, heart block, hepatic reactions, hypomania, hyponatraemia, increased appetite, insomnia, irritability, mania, movement disorders, myalgia, nausea, paraesthesia, photosensitivity, postural hypotension, pruritus,rash, sexual dysfunction, sleep disturbances, sudden death, suicidal behavior, sweating, tachycardia, taste disturbance, tinnitus, tremor, urinary retention, urticaria, vomiting, weight changes. Rare: Extrapyramidal symptoms, paralytic ileus