📋 Indications & Clinical Dosage
*Depressive illness:*
Adult: Initially 50-100 mg daily in the evening, increased gradually if necessary up to 300 mg daily, doses over 150mg daily are given in divided doses; maintenance 100 mg daily.
Children: 8-17 yrs: Initially 25 mg every night, increase by 25 mg every 4-7 day. Maintenance: 50-200 mg/day; max 200 mg/day.
*Obsessive-compulsive disorder:*
Adult: Initially 50 mg daily in the evening, increased gradually if necessary after several weeks, up to 300 mg daily; maintenance 100-300 mg daily, doses over 150mg daily are given in divided doses, if no improvement in obsessive-compulsive disorder within 10 weeks, treatment should be reconsidered.
Children: 8-17 yr: Initially 25 mg every night, increase by 25 mg after week. Maintenance: 50-200 mg/day; max 200 mg/day.
⛔ Contraindications
History of epilepsy.
⚠️ Precautions & Warnings
Hepatic or renal insufficiency.
🔄 Drug Interactions
Propranolol, theophylline, phenytoin, warfarin, MAOls, alcohol, lithium, tryptophan.
⚠️ Adverse Reactions / Side Effects
Ataxia, malaise, palpitation, tachycardia, confusion, postural hypotension, neuroleptic malignant syndrome-like event, paraesthesia, taste disturbance, nausea and vomiting, somnolence, diarrhoea, agitation, anorexia, tremor, convulsions. Rare: Abnormal liver function, usually symptomatic
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Avoid unless potential benefit outweighs risk
Lactation / Breastfeeding:
Contraindicated, avoid