📋 Indications & Clinical Dosage
*Schizophrenia and other psychoses:*
Adult: Initially 20 mg twice daily, max: 80 mg twice daily.
*Bipolar disorder, Acute manic and mixed episodes:*
Adult: Initially40 mg twice daily, increase to 60-80 mg twice daily on 2nd day of treatment; maintenance: 40-80 mg twice daily.
⛔ Contraindications
QT-interval prolongation, recent myocardial infarction, uncompensated heart failure, cardiac arrhythmias, drugs that prolong QT interval.
⚠️ Precautions & Warnings
Neuroleptic malignant syndrome, tardive dyskinesia, hyperglycaemia, seizures, CNS drugs/alcohol.
⚠️ Adverse Reactions / Side Effects
Acute dystonic reactions such as facial and skeletal muscle spasms and oculogyric crises, leucopenia, hyperprolactinaemia, acute dyskinesias, akathisia, Parkinsonism, drowsiness, insomnia, agitation, tachycardia, arrhythmias; ECG changes, hypotension, antieholinergiceffects (e.g. dry mouth, blurred vision), respiratory depression, rash, photosensitivity, hypoglycaemia, impaired tem-perature regulation, convulsions, male sexual dysfunction, rarely, agranulocytosis, tardive dyskinesia, jaundice, neuroleptic malignant syndrome, pigmentary retinopathy