TIRAZINE

*Schizophrenia and other psychoses, Short-term adjunctive management of psychomotor agitation, excitement, and violent or dangerously impulsive behavior:* Adult & Children above 12 yrs: Initially 5 mg twice daily, increased by 5mg daily after 1 week, then at intervals of 3 days, according to response. Elderly: Initially up to 2.5 mg twice daily, increased by5 mg daily after 1 week, then at intervals of 3 days, according to response. *Short-term adjunctive management of severe anxiety:* Adult: 2-4 mg daily in divided doses, increased if necessary to 6 mg daily. Elderly: Up to 2 mg daily in divided doses, increased if necessary to 6 mg daily. Children 3-6 yr: up to 500 mcg twice daily; 6-12 yr: up to 2 mg twice daily; 12-18 yr: 1-2 mg twice daily, increased if necessary to 3 mg twice daily. *Severe nausea and vomiting unresponsive to other antiemetics:* Adult: 2-4 mg daily in divided doses; max. 6 mg per day. Children 3-5 yr: up to 500 mcg twice daily; 6-12 yr: up to 2 mg twice daily; 12-18 yrs: 1-2 mg twice daily, max 3 mg twice daily.

CNS depression, comatose states, phaeochromocytoma, bone marrow depression, hepatic impairment

Elderly, Cardiovascular disease, Parkinsonism, Epilepsy

Ephedrine, barbiturates, CNS depressants, anticholinergics, antacids, oral hypoglycaemias, antihypertensixes, anticonvulsants, drugs that prolong QT interval.

Acute dystonic reactions such as facial and skeletal muscle spasms and oculogyric crises, leucopenia, hyperprolactinaemia, acute dyskinesias, akathisia, Parkinsonism, drowsiness, insomnia, agitation, tachycardia, arrhythmias; ECG changes, hypotension, antieholinergic effects (e.g. dry mouth, blurred vision), respiratory depression, rash, photosensitivity, hypoglycaemia, impaired tem-perature regulation, convulsions, male sexual dysfunction, rarely, agranulocytosis, tardive dyskinesia, jaundice, neuroleptic malignant syndrome, pigmentary retinopathy