LINZAP

*Schizophrenia, Combination therapy for mania, Prevention of recurrence in bipolar disorder:* ORAL: Adult: 10 mg daily, adjusted according to response, usual dose 5-20 mg daily, doses greater than 10 mg daily only after reassessment, when one or more factors present that might result in slower metabolism(e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase; max. 20 mg per day. *Monotherapy for mania:* ORAL: Adult: 15 mg daily, adjusted according to response, usual dose 5-20 mg daily, doses greater than 15mgdaily only after reassessment, when one or more factors present that might result in slower metabolism(e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase; max. 20 mg per day. *Control of agitation and disturbed behaviour in schizophrenia or mania:* BY IM INJ: Adult: Initially 5-10 mg for 1 dose; usual dose 10 mg for 1 dose, followed by 5-10 mg after 2 hours if required, max. 3 injections daily for 3 days; max. daily combined oral and parenteral dose20 mg, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase. Elderly: Initially 2.5-5 mg, followed by 2.5-5 mg after2 hours if required, max. 3 injections daily for3 days; max. daily combined oral and parenteral dose 20 mg, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase.

For IM use only. Inject slowly deep into muscle. Extended release IM lnj: For IM gluteal injection only after needle insertion into muscle, aspirate to verify that no blood appears. Do no massage injection site.

Narrow angle glaucoma. With intramuscular use: Acute myocardial infarction, bradycardia, recent heart surgery, severe hypotension, sick sinus syndrome, unstable angina

Hepatic or renal impairment, bone-marrow depression, diabetes mellitus, (risk of exacerbation or ketoacidosis), hypereosinophilic disorders, low leucocyte count, low neutrophil count, myeloproliferative disease, paralytic ileusprostatic hypertrophy, blood dyscrasias, seizures, tardive dyskinesia, elderly, female smokers. Monitor BP in elderly. Warn patients to report fever or muscle rigidity; suspect neuroleptic malignant syndrome.

Hepatotoxic drugs, CNS active drugs, alcohol, drugs that increase OTC interval, charcoal, smoking.

Arthralgia, increased appetite, dizziness, peripheral oedema, orthostatic hypotension, hypercholesterolaemia, hypertriglyceridaemia, increased appetite, malaise, oedema, alopecia, amnesia, bradycardia, epistaxis, hepatitis, pancreatitis, rhabdomyolysis, somnolence, weight gain