📋 Indications & Clinical Dosage
*Schizophrenia:*
Adult: 1.5 mg daily, increase in steps of 1.5 mg if required; max. 6 mg per day.
*Manic or mixed episodes associated with Bipolar I Disorder:*
Adult: Starting dose 1.5 mg daily, increase to 3mg on day 2, increase in step of 1.5mg; max. 6 mg per day.
⛔ Contraindications
Severe hepatic or renal impairment, elderly with dementia-related psychosis.
⚠️ Precautions & Warnings
Cardiovascular disease, QT prolongation, risk facter for stroke or VTE. conditions predisposing to seizures, Parkinson's disease, blood dyscrasias, diabetes, epilepsy, risk of neuroleptic malignant syndrome (discontinue), risk of tardive dyskinesia (discontinue), risk of elderly. Monitor for akathisia, for suicidal behavier, blood pressure and weight.
🔄 Drug Interactions
CYP3A4 inhibitors or reducers, P-gp substrates, drug that prolong QT, other CNS drugs.
⚠️ Adverse Reactions / Side Effects
Anxiety, Anaemia, bradyphrenia, drooling, dyslipidaemia, gait abnormal, hypertension, joint stiffness, muscle tightness, musculoskeletal stiffness, nausea, reflexes abnormal, sleep disorders, speech impairment, teeth grinding, vision disorders, cardiac disorder, delirium, depression, diabetes mellitus, dysaesthesia, eosinophilia, hepatitis toxic, suicidal behaviour, vertigo. Rare: Cataract, dysphagia, hypothyroidism, memory loss, rhabdomyolysis.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated