📋 Indications & Clinical Dosage
*Parkinsonism, Drug-induced extrapyramidal symptoms (but not tardive dyskinesia):*
Adult: 1 mg daily, then increased in steps of 2 mg every 3-5 days, adjusted according to response; maintenance 5-15 mg daily in 3-4 divided doses; max.20 mg per day
Elderly: Lower end of range preferable, not recommended for use in Parkinsons disease because of toxicity in the elderly and the risk of aggravating dementia.
*Parkinsons disease (in combination with cocareldopa or co-beneldopa):*
Adult: Maintenance 2-6 mg daily in divided doses, usenot recommended because of toxicity in the elderly andthe risk of aggravating dementia.
⛔ Contraindications
GI obstruction, myasthenia gravis
⚠️ Precautions & Warnings
Cardiovascular disease, psychotic disorders, pyrexia, those susceptible to angle-closure glaucoma, elderly, hypertension, liable to abuse,prostatic hypertrophy, hepatic or renal disorders. Withdraw treatment slowly.
🔄 Drug Interactions
Phenothiazines, antihistamines and antidepres-sants.
⚠️ Adverse Reactions / Side Effects
Anxiety, blurred vision, confusion, constipation, dizziness, dry mouth, euphoria, hallucinations, impaired memory, nausea, rash, restlessness, tachycardia, urinary retention, vomiting. Rare: Angle-closure glaucoma
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised