📋 Indications & Clinical Dosage
*Adjunctive treatment of focal seizures with or without secondary generalisation not satisfactorily controlled with other antiepileptics:*
Adult: Initially 1 g once daily or in 2 divided doses, then increased in steps of 500 mg every week, adjusted according to response; max. 3 g per day preferably in divided doses.
Children 1 month-2yrs: Initially 15-20 mg/kg twice daily (max. per dose 250 mg), to be increased over 2-3 weeks to usual maintenance dose 30-40 mg/kg twice daily (max. per dose 75 mg/kg); 2-11 yrs: Initially 15-20 mg/kg twice daily (max. per dose 250 mg), to be increased over 2-3 weeks to usual maintenance dose, 30-40 mg/kg twice daily (max. per dose 1.5 g); 12-17 yrs: Initially 250 mg twice daily, to be increased over 2-3 weeks to usual maintenance dose 1-1.5 g twice daily.
⚠️ Precautions & Warnings
Elderly, history of behavioural problems, history of depression, history of psychosis
⚠️ Adverse Reactions / Side Effects
Abdominal pain, fatigue, headache, blurred vision, agitation, aggression, depression, diplopia, dizziness, drowsiness, excitation, impaired concentration and memory, irritability, nausea, nervousness, nystagmus, oedema, paraesthesia, paranoia, speech disorder, tremor, visual field defects, vomiting, weight gain, ataxia, mania, occasional increase in seizure frequency, psychosis, rash. Rare Peripheral retinal neuropathy, retinal disorders, suicidal ideation