📋 Indications & Clinical Dosage
*Peripheral and central neuropathic pain:*
Adult: Initially 165 mg, single dose per day, increased after 3-7 days if necessary to 330 mg single dose per day. max dose 660 mg per day.
*Adjunctive therapy for focal seizures with or without secondary generalization:*
Adult: Initially 82.5 mg once daily, then increased at 7 day intervals to 330 mg once daily, increased if necessary up to 660 mg once daily.
*Generalized anxiety disorder:*
Adult: Adult: Initially 165 mg, single dose per day, increased after 3-7 days if necessary to 330 mg single dose per day. max dose 660 mg per day.
⚠️ Precautions & Warnings
Conditions that may precipitate encephalopathy, severe congestive heart failure. Avoid abrupt withdrawal (taper over at least 1 week), renal and hepatic impairment.
⚠️ Adverse Reactions / Side Effects
Aggression, blurred vision, confusion, constipation, diplopia, dizziness, drowsiness, dry mouth, lack in muscle control and movement, euphoria, flatulence, impaired memory and attention, insomnia, irritability, malaise, oedema, paraesthesia, sexual dysfunction, speech disorder, visual disturbances, visual field defects, vomiting, weight gain. Rare: congestive heart failure, convulsions, diarrhoea, encephalopathy, headache, keratitis, nausea, pruritus, QT-interval prolongation, Stevens-Johnson syndrome, suicidal ideation, urinary retention