📋 Indications & Clinical Dosage
*Treatment of acute migraine:*
Adult: 2.5 mg, followed by 2.5 mg after at least 2 hours if required, dose to be taken only if migraine recurs, then increased if necessary to 5 mg, dose to be taken only for subsequent attacks in patients not achieving satisfactory relief with 2.5mg dose; max. 10 mg per day.
⛔ Contraindications
Prinzmetals angina, severe hypertension, transient ischaemic attack, ischaemic heart disease, previous, cerebrovascular accident, previous myocardial infarction, uncontrolled hypertension, arrhythmias associated with accessory cardiac conduction pathways, coronary vasospasm, Wolff-Parkinson-White syndrome
⚠️ Precautions & Warnings
Hepatic impairment; max dose 5 mg in 24 hrs. Conditions which predispose to coronary artery disease, risk factors of ischaemic attack, elderly, should not be taken within 24 hours of any other 5HT1-receptor agonist
🔄 Drug Interactions
Ergotamine, allow interval of at least 6 hours if taking together. Other serotonin agonists, moclobemide, other MAO-A inhibitors, fluvoxamine, quinolones, cimetidine.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, dizziness, fatigue, drowsiness, dry mouth, dysphagia, flushing, headache, muscle weakness, myalgia, palpitation, paraesthesia, polyuria, tachycardia, transient increase in blood pressure, urticaria. Rare: Angina, GI infarction, ischaemiccolitis, myocardial infarction, splenic infarction
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Avoid unless the potential benefit outweighs the risk.
Lactation / Breastfeeding:
Caution advised