📋 Indications & Clinical Dosage
*Treatment of acute migraine, acute cluster headache:*
Adult: Initially 50-100 mg for 1 dose, followed by 50-100 mg after at least 2 hours if required, to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); max. 300 mg per day.
⛔ Contraindications
Coronary vasospasm, ischaemic heart disease, uncontrolled, moderate and severe hypertension, peripheral vascular disease, previous cerebrovascular accident, previous myocardial infarction, previous transient ischaemic attack, Prinzmetals angina, severe hepatic impairment
⚠️ Precautions & Warnings
Predisposition to coronary artery disease, elderly, history of seizures, mild controlled hypertension, pre-existing cardiac disease, risk factors for seizures, renal or hepatic impairment (reduce dose)
🔄 Drug Interactions
MAOIs, ergotamine, SSR1s, St. Johns Wort.
⚠️ Adverse Reactions / Side Effects
Anxiety, arthralgia, bradycardia, diarrhoea, dizziness, drowsiness, dyspnea, fatigue, flushing, myalgia, nausea, sensory disturbances, transient increase in blood pressure, vomiting, weakness, hypersensitivity reactions, hypotension, ischaemic colitis, neck stiffness. Rare: Arrhythmias, angina, dystonia, myocardial infarction, nystagmus, palpitation, Raynauds syndrome, seizures, sweating, tachycardia, transient ischaemic ECG changes, tremor, visual disturbances
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Avoid unless the potential benefit outweighs the risk.
Lactation / Breastfeeding:
withhold breast-feeding for 12 hours after treatment.