📋 Indications & Clinical Dosage
*Neuromuscular blockade (intermediate duration) during surgery and intubation:*
BY IV INJ: Adult: Initially 600 mcg/kg; (by IV injection) maintenance 150 mcg/kg, alternatively (by IV INF) maintenance 300–600 /kg/hour, adjusted according to response.
Elderly: Initially 600 mcg/kg; (by IV injection) maintenance 75–100 mcg/kg, alternatively (by IV INF) maintenance up to 400 mcg/kg/hour, adjusted according to response.
*Neuromuscular blockade (intermediate duration) during intensive care:*
BY IV INJ: Adult: Initially 600 mcg/kg, initial dose is optional; (by IV INF) maintenance 300–600 mcg/kg/hour for first hour, then (by IV INF), adjusted according to response.
💊 Mode of Administration
Administered by continuous IV infusion or via drip tubing, may be diluted with Glucose 5% or Sodium Chloride 0.9%
⚠️ Precautions & Warnings
Cardiovascular disease (reduce rate of administration), burns (increased doses may be required), electrolyte disturbances, fluid disturbances, hypothermia (lower doses required), myasthenia gravis (lower doses required), neuromuscular disorders, hepatic and renal impairment
⚠️ Adverse Reactions / Side Effects
Flushing, hypotension, bronchospasm, hypersensitivity, skin reactions, tachycardia, circulatory collapse, muscle weakness (after prolonged use in intensive care), myopathy, shock, Procedural complications. Rare: Angioedema, face oedema, malignant, hyperthermia, paralysis
🧪 Compatibility & Storage Stability
Compatibility: Stored at controlled room temperature. Freezing should be avoided.