📋 Indications & Clinical Dosage
*Acute gout:*
Adult: 500 mcg 2-4 times a day until symptoms relieved, max. 6mg per course, do not repeat course within 3 days.
*Short-term prophylaxis during initial therapy with allopurinol and uricosuric drugs:*
Adult: 500 mcg twice daily.
*Prophylaxis of familial Mediterranean fever (recurrent polyserositis):*
Adult: 0.5-2 mg once daily.
Children: Not recommended.
⚠️ Precautions & Warnings
GI disease, cardiac disease, hepatic impairment, renal impairment, elderly
⚠️ Adverse Reactions / Side Effects
Nausea, vomiting, and abdominal pain, excessive doses may also cause profuse diarrhoea, GI haemorrhage, rashes, renal and hepatic damage. Rare: peripheral neuritis, myopathy, alopecia, inhibition of spermatogenesis, and with prolonged treatment blood disorders.