📋 Indications & Clinical Dosage
*Spasticity associated with multiple sclerosis or spinal cord injury or disease:*
Adult: Initially 2 mg daily, then increased in steps of 2 mg daily in divided doses, increased at intervals of at least 3-4 days and adjust according to response; usual dose up to 24 mg daily in 3-4 divided doses; max. 36 mg per day.
🔄 Drug Interactions
Antihypertensives, diuretics, alcohol, sedatives. Caution with concomitant administration of drugs that prolong QT interval.
⚠️ Adverse Reactions / Side Effects
Altered liver enzymes (discontinue if persistently raised), dizziness, drowsiness, dry mouth, fatigue, GI disturbance, hypotension, nausea, bradycardia, asthenia, blurred vision, confusion, convulsions, hallucinations, hepatitis, insomnia, liver
Failure, syncope