BAKIN

*Chronic severe spasticity resulting from cerebrovascular accidents, cerebral palsy, meningitis, multiple sclerosis or traumatic partial section of spinal cord and head injury:* Adult: Initially 5 mg 3 times a day, gradually increased; maintenance up to 60 mg daily in divided doses, review treatment if no benefit within 6 weeks of achieving max. dose; max. 100 mg per day. Children: 2.5 mg four times daily, increasing gradually at three day intervals to required daily maintenance dose: 1-2 yrs: 10-20 mg; 2-6 yr: 20-30 mg; 6-10 yr: 30-60 mg; 10-12 yrs: 60 mg; Above 12 yrs: same as adult. *Pain of muscle spasm in palliative care:* Adult: 5-10 mg 3 times a day. *Hiccup due to gastric distension (in palliative care):* Adult: 5 mg twice daily.

Active peptic ulceration.

Cerebrovascular disease, diabetes, elderly, epilepsy, history of peptic ulcer, hypertonic bladder sphincter, Parkinsons disease, psychiatric illness, respiratory impairment, state of convulsion, hepatic or renal impairment, avoid abrupt withdrawal; may exacerbate spasticity, and precipitate autonomic dysfunction including hyperthermia, psychiatric reactions and convulsions; withdraw drug gradually over at least 1-2 weeks. Perform tests in liver disease or diabetes.

Antihypertensives, lithium, fentanyl, morphine, TCADs, ibuprofen, levodopa, carbidopa, alcohol, CNS depressants, CNS active drugs.

Agitation, anxiety, ataxia, cardiovascular depression, confusion, depression, dizziness, drowsiness, dry mouth, euphoria, GI disturbances, hallucinations, headache, hyperhidrosis, hypotension, insomnia, myalgia, nightmares, rash, respiratory depression, sedation, seizure, tremor, urinary disturbances, visual disorders, abdominal pain. Rare: changes in hepatic function, dysarthria, erectile dysfunction, paraesthesia, taste disturbances, hypothermia