CAMVIS

*Pain and inflammation in orthopaedic, dental and major surgery:* ORAL: Adults: 20 mg daily as a single dose. BY DEEP IM INJ: 20 mg daily as a single dose, Injection into upper quadrant of buttocks. SUPPOSITORY: Adults: 1 suppository daily, in severe cases 2 suppositories daily. *Rheumatoid arthritis, osteoarthrosis, ankylosing spondylitis, acute musculo-skeletal disorders:* ORAL: Adults: Initially 40 mg daily for 2 days then 20 mg daily for 7-14 days. BY DEEP IM INJ: 40 mg daily dose for 2 days, injection into upper quadrant of buttocks. Maintenance:20 mg by oral administration. SUPPOSITORY: Adults: 1 suppository daily, in severe cases 2 suppositories daily. *Acute gout:* ORAL: Adults: Initially 40 mg as a single dose then 40 mg daily in single or divided doses for next 4-6 days. BY DEEP IM INJ: 20 mg daily as a single dose, Injection into upper quadrant of buttocks.Maintenance:40 mg by oral administration. SUPPOSITORY: Adults: 1 suppository daily, in severe cases 2 suppositories daily.

It should be administered using aseptic technique into a relatively large muscle. The preferred site is the upper outer quadrant of the buttock (i.e. gluteus maximus). Aspiration is necessary to help avoid inadvertent injection into a blood vessel.

Active GI bleeding or ulceration, history of GI bleeding or perforation related to previous NSAID therapy, history of recurrent GI haemorrhage or ulceration (two or more distinct episodes), severe heart failure, aspirin/anti-inflammatory induced allergy, hepatic and renal failure

Allergic disorders, cardiac impairment, cerebrovascular disease, coagulation defects, connective-tissue disorders, Crohns disease, elderly, heart failure, ischaemic heart disease, peripheral arterial disease, risk factors for cardiovascular events, ulcerative colitis (may be exacerbated), uncontrolled hypertension, renal or hepatic impairment, monitor on long-term therapy, asthma

Anticoagulants, other NSAID5, hypoglycaemics, lithium.

Abdominal pain, angioedema, blood disorders, bronchospasm, colitis, Crohns disease, depression, diarrhoea, dizziness, drowsiness, fluid retention, GI bleeding and ulceration, GI disturbances, haematuria, headache, hearing disturbances, hypersensitivity reactions, nausea, nervousness, photosensitivity, raised blood pressure, rashes, renal failure (especially in patients with preexisting renal impairment),tinnitus, vertigo. Rare: Hepatic damage, interstitial fibrosis associated with NSAIDs, Stevens-Johnson syndrome, toxic epidermal necrolysis, visual disturbances, exacerbation of symptoms in asthma, thrombocytopenia, aseptic meningitis, CNS disturbances.