📋 Indications & Clinical Dosage
*Pain of osteoarthritis, rheumatoid arthritis & ankylosing spondylitis in patients at risk of developing NSAID associated gastric ulcers:*
Adult: 375/20 mg to 500/20 mg twice daily. Reduced dose in elderly patients.
⛔ Contraindications
Hypersensitivity to any component of medicines or substituted benzimidazoles, history of asthma, urticaria or other allergic-type reactions after taking aspirin or other NSAIDs, during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery, late pregnancy, hepatic, and renal failure.
⚠️ Precautions & Warnings
Allergic disorders, cardiac impairment,
cerebrovascular disease, coagulation defects,
connective-tissue disorders, Crohn-s disease, elderly,
heart failure, ischaemic heart disease, peripheral
arterial disease, risk factors for cardiovascular
events, uncontrolled hypertension, renal or hepatic impairment,
monitor on long-term therapy, asthma.
🔄 Drug Interactions
Anticoagulants, antiplatelets, hydantoins, sulfo-nylureas, quinolones, sulphonamides, diuretics, lithium, beta-blockers, probenecid, methotrexate, cyclosporin, corticosteroids, SSRIs, cardiac glycosides, mifepristone, tacrolimus, zidovudine, other NSAIDs.
⚠️ Adverse Reactions / Side Effects
Angioedema, blood disorders, bronchospasm, colitis, Crohns disease, depression, diarrhoea, dizziness, drowsiness, fluid retention, haematuria, headache, hypersensitivity reactions, nausea, nervousness, photosensitivity, raised blood pressure, rashes, renal failure, tinnitus, vertigo. Rare:
Hepatic damage, interstitial fibrosis associated
with NSAIDs, Stevens-Johnson syndrome, toxic epidermal
necrolysis, visual disturbances, exacerbation
of symptoms in asthma, thrombocytopenia,
aseptic meningitis, CNS disturbances.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy
Lactation / Breastfeeding:
Contraindicated