📋 Indications & Clinical Dosage
*Pain and inflammation in rheumatic disease:*
Adult & Children above 16 yrs: 0.5-1 g daily in 1-2 divided doses.
*Pain and inflammation in musculoskeletal disorders, Dysmenorrhoea:*
Adult & Children above 16 yrs: Initially 500 mg, then 250 mg every 6-8 hours as required, max. dose after the first day 1.25 g daily.
*Acute gout:*
Adult & Children above 16yrs: Initially 750 mg, then 250 mg every 8 hours until attack has passed.
*Migraine:*
Adult & Children above 16 yrs: 750 mg at once then 250 mg or 500 mg as needed; max 1250 mg daily.
*Post-operative pain:*
Adult & Children above 16 yr: 500 mg twice daily.
*Juvenile idiopathic arthritis:*
Children 6-18 yrs: 5-7.5 mg/kg twice daily, max 1 gm/day.
⛔ Contraindications
Active GI bleeding or ulceration, history of GI bleeding or perforation related to previous NSAID therapy, history of recurrent GI haemorrhage or ulceration (two or more distinct episodes), severe heart failure, aspirin/anti-inflammatory induced allergy, hepatic and renal failure; creatinine clearance <20 ml/min.
⚠️ Precautions & Warnings
Allergic disorders, cardiac impairment, cerebrovascular disease, coagulation defects, connective-tissue disorders, Crohns disease, elderly, heart failure, ischaemic heart disease, peripheral arterial disease, risk factors for cardiovascular events, ulcerative colitis (may be exacerbated), uncontrolled hypertension, renal or hepatic impairment, monitor on long-term therapy, asthma
🔄 Drug Interactions
Anticoagulants, antiplatelets, hydantoins, sulfo-nylureas, quinolones, sulphonamides, diuretics, lithium, beta-blockers, probenecid, methotrexate, cyclosporin, corticosteroids, SSRIs, cardiac glycosides, mifepristone, tacrolimus, zidovudine, other NSAIDs.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, angioedema, blood disorders, bronchospasm, colitis, Crohns disease, depression, diarrhoea, dizziness, drowsiness, fluid retention, GI bleeding and ulceration, GI disturbances, haematuria, headache, hearing disturbances, hypersensitivity reactions, nausea, nervousness, photosensitivity, raised blood pressure, rashes, renal failure (especially in patients with preexisting renal impairment), tinnitus, vertigo. Rare: Hepatic damage, interstitial fibrosis associated with NSAIDs,Stevens-Johnson syndrome, toxic epidermal necrolysis, visual disturbances, exacerbation of symptoms in asthma, thrombocytopenia, aseptic meningitis, CNS disturbances.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy
Lactation / Breastfeeding:
Contraindicated