NILTIS

*Pain and inflammation in osteoarthritis and rheumatoid arthritis:* Adult: 1 g once daily at night Elderly: 0.5-1 g daily. *Pain and inflammation in osteoarthritis and rheumatoid arthritis with severe and persistent symptoms:* Adult: 0.5-1 in the morning and 1 g at night Elderly: 0.5-1 g daily.

Active GI bleeding or ulceration, history of GI bleeding or perforation related to previous NSAID therapy, history of recurrent GI haemorrhage or ulceration (two or more distinct episodes), severe heart failure, aspirin/anti-inflammatory induced allergy, hepatic and renal failure; creatinine clearance <20 ml/min.

Allergic disorders, cardiac impairment, cerebrovascular disease, coagulation defects, connective-tissue disorders, Crohns disease, elderly, heart failure, ischaemic heart disease, peripheral arterial disease, risk factors for cardiovascular events, ulcerative colitis (may be exacerbated), uncontrolled hypertension, renal or hepatic impairment, monitor on long-term therapy, asthma

Anticoagulants, antiplatelets, hydantoins, sulfonylureas, quinolones, sulphonamides, diuretics, lithium, beta-blockers, probenecid, methotrexate, cyclosporin, corticosteroids, SSRIs, cardiac glycosides, mifepristone, tacrolimus, zidovudine, other NSAIDs.

Abdominal pain, angioedema, blood disorders, bronchospasm, colitis, Crohns disease, depression, diarrhoea, dizziness, drowsiness, fluid retention, GI bleeding and ulceration, GI disturbances, haematuria, headache, hearing disturbances, hypersensitivity reactions, nausea, nervousness, photosensitivity, raised blood pressure, rashes, renal failure, tinnitus, vertigo. Rare: Hepatic damage, interstitial fibrosis associated with NSAIDs, Stevens-Johnson syndrome, toxic epidermal necrolysis, visual disturbances, exacerbation of symptoms in asthma, thrombocytopenia, aseptic meningitis, CNS disturbances.