📋 Indications & Clinical Dosage
*Prophylaxis of organ rejection in heart allograft recipients:*
BY IV INF: Adult: 1-2.5 mg/kg daily for 3-5 days, to be given over at least 6 hours.
*Prophylaxis of organ rejection in renal allograft recipients:*
BY IV INF: Adult: 1-1.5 mg/kg daily for 3-9 days, to be given over at least 6 hours.
*Treatment of corticosteroid-resistant allograft rejection in renal transplantation:*
BY IV INF: Adult: 1.5 mg/kg daily for 7-14 days, to be given over at least 6 hours.
💊 Mode of Administration
IV infusion using a high-flow vein; Anti-thymocyte globulin should be infused over a minimum of 6 hours for the first infusion and over at least 4 hours on subsequent days of therapy. Antithymocyte globulin should be administered through an in-line 0.22 mcm filter.
⛔ Contraindications
Infection, pregnancy and lactation
⚠️ Precautions & Warnings
Tolerability is increased by pretreatment with an IV corticosteroid and antihistamine; an antipyretic drug such as paracetamol may also be beneficial.
🔄 Drug Interactions
Live vaccines. Monitor blood count
⚠️ Adverse Reactions / Side Effects
Anaphylaxis, cytokine release syndrome, diarrhoea, dysphagia, fever, hypotension, increased susceptibility to infection, increased susceptibility to malignancy, infusion-related reactions, lymphopenia, myalgia, nausea, neutropenia, pruritus, rash, serum sickness, shivering, thrombocytopenia, vomiting
🧪 Compatibility & Storage Stability
Stability & Storage: Store in refrigerator between 2C-8C (36F-46F). Protect from light. Do not freeze. Reconstituted vials of antithymocyte globulin should be used within 4 hours. Infusion solutions of anti-thymocyte globulin must be used immediately. Any unused drug remaining after infusion must be discarded.