📋 Indications & Clinical Dosage
*Reduction in duration of neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy for malignancy:*
BY SC INJ: Adult: 6 mg for each chemotherapy cycle, to be started at least 24 hours after chemotherapy.
Children: Not recommended.
💊 Mode of Administration
Rotate injection sites among thigh, abdomen (except for 2 inches around navel), buttocks and outer, upper arms, should not be administered in the period between 14 days before and 24 hours after administration of cytotoxic chemotherapy.
⛔ Contraindications
Hypersensitivity to E. coli derived proteins, secondary acute or chronic leukaemia, myelodysplastic syndrome.
⚠️ Precautions & Warnings
Acute leukaemia, myelosuppressive chemotherapy, high dose chemotherapy, respiratory distress syndrome (discontinue) Monitor platelet count, haematocrit and for signs of splenic rupture, Sickle cell anaemia.
🔄 Drug Interactions
Antimetabolites.
⚠️ Adverse Reactions / Side Effects
Skeletal, joint and muscle pain, inj site pain, non-cardiac chest pain, headache, splenomegaly, reversible elevated uric acid, allergic reactions including anaphylaxis, capillary leak syndrome (including fatal cases). Rare; Splenic rupture
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Risk cannot be ruled out, use only if extremely necessary.
Lactation / Breastfeeding:
Contraindicated or not recommended.
🧪 Compatibility & Storage Stability
Stability & Storage: Store refrigerated between 2C-8C (36F-46F), syringes should be kept in their carton to protect from light until time of use. Before injection, may be allowed to reach room temperature for a maximum of 48 hours, but should be protected from light, if left at room temperature for more than 48 hours should be discarded. Freezing should be avoided.