📋 Indications & Clinical Dosage
*Acute leukaemia, Chronic myeloid leukaemia:*
Adult: 100-200 mg/m2 daily, can be given at various stages of treatment in short-term cycles usually for 5-7 day or until remission is attained.
Children: 3.3 mg/kg/day in divided doses for 4 days.
⛔ Contraindications
Viraemic states, marrow aplasia, severe anaemia, leucopenia, thrombocytopenia, hepatic or renal failure.
⚠️ Precautions & Warnings
Haematological monitoring required, risk of infection. Long-term therapy is not recommended because of the high risk of liver toxicity.
🔄 Drug Interactions
Mercaptopurine, busulfan, aminosalicylates.
⚠️ Adverse Reactions / Side Effects
Alopecia, bone-marrow suppression, hepatotoxicity (discontinue), hyperuricaemia, leukopenia, nausea, oral mucositis, stomatitis, thromboembolism, tumourlysis syndrome, vomiting. Rare: Intestinal necrosis, intestinal perforation
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Positive evidence of risk: Avoid
Lactation / Breastfeeding:
Contraindicated. Discontinue breast-feeding