📋 Indications & Clinical Dosage
*Benign gastric ulcer:*
Adult: 20 mg daily for 8 weeks, dose to be taken in the morning
*Duodenal ulcer:*
Adult: 20 mg daily for 4 weeks, dose to be taken in the morning
*Gastro-oesophageal reflux disease:*
Adult: 20 mg once daily for 4-8 weeks; maintenance
10-20 mg daily
*Gastro-oesophageal reflux disease (symptomatic treatment in the absence of oesophagitis):*
Adult: 10 mg daily for up to 4 weeks, then 10 mg daily if required
*Zollinger-Ellison syndrome:*
Adult: Initially 60 mg once daily, adjusted according to response, doses above 100mg daily given in 2 divided doses; max. 120 mg per day
*Helicobacter pylori eradication:*
Adult: 20 mg twice daily, in combination with amoxicillin or metronidazole and clarithromycin
Children: Not recommended.
⚠️ Precautions & Warnings
Exclude gastric or oesophageal malignancy before treatment, severe hepatic impairment. Monitor patients on long term therapy.
🔄 Drug Interactions
Ketoconazole, itraconazole.
⚠️ Adverse Reactions / Side Effects
Cough, influenza like syndrome, rhinitis, chest pain, nervousness, Anorexia, weight gain, headache, GI upset, rash, asthenia, dry mouth.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.