📋 Indications & Clinical Dosage
*Congenital cobalamine malabsorption, homocystenemia, methylmalonylaciduria, peripheral neuropathies, pernicious anaemia, vit B12 deficiency:*
ORAL: Adults: 500 mcg 3 times daily. Children: Not recommended.
BY IM OR IV INJ: Adults: 1 amp by injection three times a week.
Maintenance:1 amp in a single administration
Children: Not recommended.
⚠️ Precautions & Warnings
Prolonged use is not recommended, patients whose occupation requires handling of mercury or its compounds, pregnancy and lactation.
⚠️ Adverse Reactions / Side Effects
Cardiac arrhythmia, aggravation of acidosis (discontinue), headache, nausea, vomiting, anorexia, diarrhoea, tachycardia, sweating, skin rash, hot sensation, allergic hypersensitivity reaction.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.