📋 Indications & Clinical Dosage
*Chronic stable angina Pectoris, unstable angina, myocardial infarction, ischemic cerebrovascular disorder, TIA, cerebral infarction, with history of gasteric/duodenal ulcer:*
Adult: 10/100 mg once daily.
*After coronary artery bypass grafting(CABG) or percutaneous transluminal coronary angioplasty(PTCA) with history of gasteric/duodenal ulcer:*
Adult: 10/100 mg once daily.
⛔ Contraindications
Peptic ulcer, blood abnormality, bleeding tendency, bronchial asthma, renal disorder, hepatic disorder, alcohol dependents, scheduled surgery, catrdiac catheter test, tooth extraction.
⚠️ Precautions & Warnings
Elevation of intragastric pH, metabolic disorder, elderly. Monitor blood pressure, endoscopic examination in prolonged use. Consult physician if a surgery is scheduled during treatmant.
🔄 Drug Interactions
Drugs depend on gastric pH for absorption (atazanavir, rilpivirine, nelfinavir), Itraconazole, digoxin, tyrosine kinase inhibitors, RAS Inhibitors, anticoagulant and antiplatelets
⚠️ Adverse Reactions / Side Effects
General malaise, fever, shortness of breath, esophagitis, gasteric distress, itch, anemia, decrease blood pressure and edema.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.