📋 Indications & Clinical Dosage
*GI disorders associated with motility disturbances such as gastro-oesophageal refluxdisease, non-ulcer dyspepsia and delayed gastric emptying:*
Adults: 1 mg three times daily before meals.
Children: Not recommended.
⛔ Contraindications
Hypersensitivity to drug.
⚠️ Precautions & Warnings
To be used with caution to elderly because it enhances the action of acetylcholine, patients with GI hemorrhage, mechanical GI obstruction or perforation, a history of dyskinesia induced by neuroleptics.
🔄 Drug Interactions
Atropine, drugs that enhance the effect of medicines used for the illness of CNS and for insomnia, digoxin.
⚠️ Adverse Reactions / Side Effects
Angioedema, gynacomastia, drowsiness, confusion, extrapyramidal effects, diarrhoea, sedation, cutaneous reactions.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.